CD40, autophagy and Toxoplasma gondii

Memórias do Instituto Oswaldo Cruz

Carlos S Subauste¹ 

[1] ,University School of Medicine Case Western Reserve Department of Pathology

关键词: macrophage;    lysosome;    endosome;    IFN-³;    nitric oxide;   

DOI  :  10.1590/S0074-02762009000200020

来源: SciELO

【 摘 要 】

Toxoplasmagondii represents a pathogen that survives within host cells by preventing the endosomal-lysosomal compartments from fusing with the parasitophorous vacuoles. The dogma had been that the non-fusogenic nature of these vacuoles is irreversible. Recent studies revealed that this dogma is not correct. Cell-mediated immunity through CD40 re-routes the parasitophorous vacuoles to the lysosomal compartment by a process called autophagy. Autophagosome formation around the parasitophorous vacuole results in killing of the T. gondii. CD40-induced autophagy likely contributes to resistance against T. gondii particularly in neural tissue.

【 授权许可】

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