PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Drug Delivery

Rongrong Wang¹  Xun Zhang²  Bolun Zhang²  Ruowei Sun²  Chuanpin Chen³  Wenfang Liu³  Yue Su³  Qubo Zhu³ 

[1] Hunan Institute for Drug Control;Hunan Zaochen Nanorobot Co., Ltd;Xiangya School of Pharmaceutical Sciences, Central South University;

关键词: biodegradable microspheres;    plga;    preparation methods;    drug delivery;    applications;   

DOI  :  10.1080/10717544.2021.1938756

来源: DOAJ

【 摘 要 】

Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocular-related diseases.

【 授权许可】

Unknown