Resveratrol Derivatives as Potential Treatments for Alzheimer’s and Parkinson’s Disease

Frontiers in Aging Neuroscience

Ana Luiza Muccillo-Baisch¹  Raif Gregorio Nasre-Nasser¹  Dennis Costa-Silva¹  Mariana Appel Hort¹  Michele Goulart Santos¹  Lúcia Emanueli Schimith¹  Bruno Dutra Arbo²  Corinne André-Miral³ 

[1] Instituto de Ciências Biológicas, Universidade Federal do Rio Grande (FURG), Rio Grande, Brazil;Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil;Université de Nantes, CNRS, Unité de Fonctionnalité et Ingénierie des Protéines (UFIP), UMR 6286, Nantes, France;

关键词: neurodegenerative diseases;    neurodegeneration;    neuroprotection;    polyphenols;    stilbene;    aging;   

DOI  :  10.3389/fnagi.2020.00103

来源: DOAJ

【 摘 要 】

Neurodegenerative diseases are characterized by the progressive loss of neurons in different regions of the nervous system. Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most prevalent neurodegenerative diseases, and the symptoms associated with these pathologies are closely related to the regions that are most affected by the process of neurodegeneration. Despite their high prevalence, currently, there is no cure or disease-modifying drugs for the treatment of these conditions. In the last decades, due to the need for the development of new treatments for neurodegenerative diseases, several authors have investigated the neuroprotective actions of naturally occurring molecules, such as resveratrol. Resveratrol is a stilbene found in several plants, including grapes, blueberries, raspberries, and peanuts. Studies have shown that resveratrol presents neuroprotective actions in experimental models of AD and PD, however, its clinical application is limited due to its rapid metabolism and low bioavailability. In this context, studies have proposed that structural changes in the resveratrol molecule, including glycosylation, alkylation, halogenation, hydroxylation, methylation, and prenylation could lead to the development of derivatives with enhanced bioavailability and pharmacological activity. Therefore, this review article aims to discuss how resveratrol derivatives could represent viable molecules in the search for new drugs for the treatment of AD and PD.

【 授权许可】

Unknown