Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis

Parasite

Bucheton Bruno¹  Jamonneau Vincent¹  Courtin Fabrice¹  Kaboré Jacques¹  Compaoré Charlie²  Kaba Dramane³  Ilboudo Hamidou⁴  Lejon Veerle⁵  Büscher Philippe⁶  Camara Oumou⁷  Camara Mamadou⁷  N’Gouan Emmanuel Kouassi⁸  Koffi Mathurin⁹ 

[1] ;Centre International de Recherche-Développement sur l’Elevage en zones Subhumides (CIRDES), Unité de recherches sur les maladies à vecteurs et biodiversité;Institut Pierre Richet, Unité de Recherche « Trypanosomoses »;Institut de Recherche en Sciences de la Santé (IRSS), Unité de Recherche Clinique de Nanoro (URCN);Institut de Recherche pour le Développement (IRD), UMR INTERTRYP IRD-CIRAD, Université de Montpellier, TA A-17/G, Campus International de Baillarguet;Institute of Tropical Medicine, Department of Biomedical Sciences;Programme National de Lutte contre la Trypanosomose Humaine Africaine;Projet de Recherche Clinique sur les Trypanosomoses;Université Jean Lorougnon Guédé, Laboratoire de biodiversité et Gestion durable des écosystèmes tropicaux, Unité de Recherche en Génétique et Epidémiologie moléculaire;

关键词: human african trypanosomiasis;    trypanosoma brucei gambiense;    elimination;    diagnosis;    transmission;    immune trypanolysis;   

DOI  :  10.1051/parasite/2019066

来源: DOAJ

【 摘 要 】

The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area.

【 授权许可】

Unknown