The Participation of Microglia in Neurogenesis: A Review

Brain Sciences

Idoia Blanco-Luquin¹  Maite Mendioroz¹  DiegoR. Pérez-Rodríguez² 

[1]Neuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra-IdiSNA (Navarra Institute for Health Research), Universidad Pública de Navarra (UPNA), 31008 Pamplona, Navarra, Spain

[2]Neurophysiology Department, Complejo Hospitalario de Navarra-IdiSNA (Navarra Institute for Health Research), 31008 Pamplona, Navarra, Spain

关键词: microglia;    inflammation;    adult neurogenesis;    age;    neurodegenerative diseases;   

DOI  :  10.3390/brainsci11050658

来源: DOAJ

【 摘 要 】

Adult neurogenesis was one of the most important discoveries of the last century, helping us to better understand brain function. Researchers recently discovered that microglia play an important role in this process. However, various questions remain concerning where, at what stage, and what types of microglia participate. In this review, we demonstrate that certain pools of microglia are determinant cells in different phases of the generation of new neurons. This sheds light on how cells cooperate in order to fine tune brain organization. It also provides us with a better understanding of distinct neuronal pathologies.

【 授权许可】

Unknown