Oenothein B Suppresses Lipopolysaccharide (LPS)-Induced Inflammation in the Mouse Brain

International Journal of Molecular Sciences

Satoshi Okuyama¹  Nahomi Makihata¹  Morio Yoshimura²  Yoshiaki Amakura²  Takashi Yoshida²  Mitsunari Nakajima¹ 

[1] Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan; E-Mails:;Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan; E-Mails:

关键词: oenothein B;    lipopolysaccharide;    depression-like behavior;    hippocampus;    inflammation;    microglia;    COX-2;    astrocyte;   

DOI  :  10.3390/ijms14059767

来源: mdpi

【 摘 要 】

Oenothein B has been recently evaluated for its ability to affect inflammatory responses in peripheral tissues. In this study, we examined its effect on the damage to the central nervous system due to systemic inflammation. For this purpose, ICR mice were injected with an intraperitoneal (i.p.) dose of lipopolysaccharide (LPS; 1 mg/kg mouse). When oenothein B was administered per os (p.o.), it suppressed (1) LPS-induced abnormal behavior in open field; (2) LPS-induced microglial activation in the hippocampus and striatum; and (3) LPS-induced cyclooxygenase (COX)-2 production in the hippocampus and striatum of these mice. These results suggest that oenothein B had the ability to reduce neuroinflammation in the brain during systemic inflammation.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland