Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies

Cells

AjayGodwin Potnuri¹  Prasanna Krishnamurthy²  Sherin Saheera³ 

[1] Department of Animal Physiology, Indian Council for Medical Research—National Animal Resource Facility for Biomedical Research, Genome Valley, Shamirpet, Hyderabad, Telangana 500078, India;Department of Biomedical Engineering, School of Medicine and School of Engineering, The University of Alabama at Birmingham, 1675 University Blvd, Volker Hall G094, Birmingham, AL 35294, USA;Department of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA;

关键词: exosomes;    aging;    extracellular vesicles;    miRNA;    COVID-19;   

DOI  :  10.3390/cells9091974

来源: DOAJ

【 摘 要 】

Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular structures (exosomes) range from 30 to 140 nm and are present in various biological fluids such as saliva, plasma, urine etc. These cargo-laden extracellular vesicles arise from endosome-derived multivesicular bodies and are known to carry proteins and nucleic acids. Exosomes are involved in multiple physiological and pathological processes, including cellular senescence. Exosomes mediate signaling crosstalk and play a critical role in cell–cell communications. Exosomes have evolved as potential biomarkers for aging-related diseases. Aging, a physiological process, involves a progressive decline of function of organs with a loss of homeostasis and increasing probability of illness and death. The review focuses on the classic view of exosome biogenesis, biology, and age-associated changes. Owing to their ability to transport biological information among cells, the review also discusses the interplay of senescent cell-derived exosomes with the aging process, including the susceptibility of the aging population to COVID-19 infections.

【 授权许可】

Unknown