Pro-Inflammatory Diet Is Associated with Adiposity during Childhood and with Adipokines and Inflammatory Markers at 11 Years in Mexican Children

Nutrients

JamesR. Hébert¹  Nitin Shivappa¹  AnaCarolina Ariza²  LiliaSusana Pedraza²  Ivonne Ramírez Silva²  JuanA. Rivera Dommarco²  Sofia Barragán-Vázquez²  Albino Barraza-Villarreal³  Isabelle Romieu³  Eduardo Ortiz-Panozo³  Laura Avila-Jiménez⁴  Elena Zambrano⁵  LuisA. Reyes Castro⁵  AryehD. Stein⁶  Usha Ramakrishnan⁶  Reynaldo Martorell⁶ 

[1] Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics, University of South Carolina, 915 Greene Street, Suite 241, Columbia, SC 29208, USA;Center for Nutrition and Health Research, Instituto Nacional de Salud Pública, Av. Universidad 655, Col. Santa María Ahuacatitlán, Cerrada los pinos y Caminera, Cuernavaca C.P. 62100, Morelos, Mexico;Center for Population Health Research, Instituto Nacional de Salud Pública, Av. Universidad 655, Col. Santa María Ahuacatitlán, Cerrada los pinos y Caminera, Cuernavaca C.P. 62100, Morelos, Mexico;Coordinación Auxiliar Médica de Investigación en Salud, Delegación Estatal Morelos, Instituto Mexicano del Seguro Social, Morelos C.P. 62000, Mexico;Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City C.P. 14080, Mexico;Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA;

关键词: inflammation;    diet;    children’s dietary inflammatory index;    leptin/adiponectin ratio;    CRP;    IL-6;   

DOI  :  10.3390/nu12123658

来源: DOAJ

【 摘 要 】

There is limited evidence about the inflammatory potential of diet in children. The aim of this study was to evaluate the association between the Children’s Dietary Inflammatory Index (C-DII) from 5 to 11 years with adiposity and inflammatory biomarkers in Mexican children. We analyzed 726 children from a birth cohort study with complete dietary information and measurements to evaluate adiposity at 5, 7 and 11 y and 286 children with IL-6, hsCRP, leptin and adiponectin information at 11 y. C-DII trajectories were estimated using latent class linear mixed models. We used linear mixed models for adiposity and logistic and multinomial regression for biomarkers. In girls, each one-point increase in C-DII score was associated with greater adiposity (abdominal-circumference 0.41%, p = 0.03; skinfold-sum 1.76%, p = 0.01; and BMI Z-score 0.05, p = 0.01). At 11 y the C-DII was associated with greater leptin (34% ≥ 13.0 ng/mL, p = 0.03) and hsCRP concentrations (29% ≥ 3.00 mg/L, p = 0.06) and lower adiponectin/leptin ratio (75% < 2.45, p = 0.02). C-DII trajectory 3 in boys was associated with a 75.2% (p < 0.01) increase in leptin concentrations and a 37.9% decrease (p = 0.02) in the adiponectin/leptin ratio. This study suggests that the inflammatory potential of diet may influence adiposity in girls and the homeostasis of adipose tissue and chronic subclinical inflammation in 11-year-old children.

【 授权许可】

Unknown