Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents

Molecules

Saher M. Kandeel¹  Abdou O. Abdelhamid²  Nadia A. Abdelriheem²  Sobhi M. Gomha² 

[1] Chemistry of Natural Compounds, Department National Research Center, Dokki 12622, Egypt;Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt;

关键词: thiazoles;    pyrazoles;    coupling reactions;    thiosemicarbazides;    molecular docking;    anti-cancer activity;   

DOI  :  10.3390/molecules21070929

来源: DOAJ

【 摘 要 】

2-(3-(1H-Indol-3-yl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-substituted-5-(substituted diazenyl)thiazoles and 2-(1H-indol-3-yl)-9-substituted-4,7-disubstituted pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(7H)-ones were synthesized via reaction of hydrazonoyl halides with each of 3-(1H-indol-2-yl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide and 7-(1H-indol-3-yl)-2- thioxo-5-substituted-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones, respectively. Also, hydrazonoyl halides were reacted with N’-(1-(1H-indol-3-yl)ethylidene)-2-cyanoacetohydrazide to afford 1,3,4-thiadiazole derivatives. Structures of the new synthesis were elucidated on the basis of elemental analysis, spectral data, and alternative synthetic routes whenever possible. Fifteen of the new compounds have been evaluated for their antitumor activity against the MCF-7 human breast carcinoma cell line. The results indicated that many of the tested compounds showed moderate to high anticancer activity when compared with doxorubicin as a reference drug.

【 授权许可】

Unknown