Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents

Molecules

Mohie E. M. Zayed¹  Yahia Nasser Mabkhot²  Amany M. G. Mohamed³  Thoraya A. Farghaly³  Sobhi M. Gomha³ 

[1] Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah B.O. 208203, Saudi Arabia;Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh-11451, Saudi Arabia;Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt;

关键词: thiophenes;    pyrazoles;    thiazoles;    antimicrobial activity;    microwave irradiation;   

DOI  :  10.3390/molecules22030346

来源: DOAJ

【 摘 要 】

In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trimethoprim/sulphamethoxazole. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used.

【 授权许可】

Unknown