Synovial fluid presepsin as a novel biomarker for the rapid differential diagnosis of native joint septic arthritis from crystal arthritis

International Journal of Infectious Diseases

Kazushige Seki¹  Tomoya Okazaki²  Hiroshi Tanaka³  Manabu Yamamoto⁴  Takashi Sakai⁴  Kenji Hirata⁴  Kazuhiro Yamazaki⁵  Toshihiro Seki⁵  Daisuke Nakashima⁵  Takashi Imagama⁵  Yuta Matsuki⁵  Atsunori Tokushige⁵ 

[1] Corresponding author.;Department of Orthopedic Surgery, St. Hill Hospital, 3-7-18, Imamurakita, Ube 755-0155, Japan;Department of Orthopedic Surgery, Tokuyama Central Hospital, 1-1, Koda, Shunan, 745-8522, Japan;Department of Orthopedic Surgery, Yamaguchi Prefectural Grand Medical Center, 10077, Osaki, Hofu, 747-8511, Japan;Department of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1, Minamikogushi, Ube 755-8505, Japan;

关键词: Presepsin;    Synovial fluid;    Native joint septic arthritis;    Crystal arthritis;    Differential diagnosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: To investigate whether presepsin can be used as a novel biomarker to differentiate between native joint septic arthritis (NJSA) and crystal arthritis (CA). Methods: This study included 75 patients diagnosed with either NJSA (n = 21) or CA (n = 54). Presepsin in synovial fluid and blood, C-reactive protein, and procalcitonin were measured and compared between the NJSA and CA groups. Receiver operating characteristic (ROC) curve analyses were performed to differentiate between the two groups. Results: Synovial fluid and blood presepsin were significantly higher in the NJSA group than in the CA group (p < 0.0001 and p < 0.01, respectively). The area under the ROC curve for synovial fluid presepsin in the NJSA group compared with the CA group was 0.93 (sensitivity 85.7%, specificity 85.2%, positive predictive value 69.2%, negative predictive value 93.9%, positive likelihood ratio 5.79, negative likelihood ratio 0.17). Among the tests, synovial fluid presepsin was the most accurate. Conclusions: Measurement of synovial fluid presepsin is reliable for the early diagnosis of NJSA, and synovial fluid presepsin could be used as a novel biomarker for differentiating between NJSA and CA.

【 授权许可】

Unknown