Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study

BMC Research Notes

Osamu Umegaki¹  Yuichiro Shimoyama¹  Noriko Kadono¹  Toshiaki Minami² 

[1] Department of Anesthesiology, Osaka Medical College, Intensive Care Unit, Osaka Medical College Hospital, 2-7 Daigaku-machi, 569-8686, Takatsuki, Osaka, Japan;Department of Anesthesiology, Osaka Medical College, Osaka Medical College Hospital, 569-8686, Takatsuki, Osaka, Japan;

关键词: Presepsin;    Sepsis;    Sepsis-3 definition;    Inflammation-based prognostic score;    Mortality;   

DOI  :  10.1186/s13104-021-05659-9

来源: Springer

【 摘 要 】

ObjectiveSepsis is a major cause of mortality for critically ill patients. This study aimed to determine whether presepsin values can predict mortality in patients with sepsis.ResultsReceiver operating characteristic (ROC) curve analysis, Log-rank test, and multivariate analysis identified presepsin values and Prognostic Nutritional Index as predictors of mortality in sepsis patients. Presepsin value on Day 1 was a predictor of early mortality, i.e., death within 7 days of ICU admission; ROC curve analysis revealed an AUC of 0.84, sensitivity of 89%, and specificity of 77%; and multivariate analysis showed an OR of 1.0007, with a 95%CI of 1.0001–1.0013 (p = 0.0320).

【 授权许可】

CC BY