Genistein, a Potential Phytochemical against Breast Cancer Treatment-Insight into the Molecular Mechanisms

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Md. Sharif Khan¹  Dipta Dey²  Priyanka Paul²  Abdullah Al Mamun³  Md Sohel³  Arifa Setu³  Suraiya Aktar⁴  Md. Arju Hossain⁵  Md. Al Amin⁵  Habiba Sultana⁵  Partha Biswas⁶  Bonglee Kim⁷  Md. Nurul Islam⁸  Md. Ataur Rahman⁹ 

[1] ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh;Biochemistry and Molecular Biology Department, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalgonj 8100, Bangladesh;Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, Bangladesh;Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi 6205, Bangladesh;Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, Bangladesh;Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology (JUST), Jashore 7408, Bangladesh;Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea;Department of Pharmacy, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, Bangladesh;Global Biotechnology & Biomedical Research Network (GBBRN), Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh;

关键词: genistein;    breast cancer;    molecular pharmacology;    anticancer mechanism;    synergistic activity;   

DOI  :  10.3390/pr10020415

来源: DOAJ

【 摘 要 】

Breast cancer (BC) is one of the most common malignancies in women. Although widespread successful synthetic drugs are available, natural compounds can also be considered as significant anticancer agents for treating BC. Some natural compounds have similar effects as synthetic drugs with fewer side effects on normal cells. Therefore, we aimed to unravel and analyze several molecular mechanisms of genistein (GNT) against BC. GNT is a type of dietary phytoestrogen included in the flavonoid group with a similar structure to estrogen that might provide a strong alternative and complementary medicine to existing chemotherapeutic drugs. Previous research reported that GNT could target the estrogen receptor (ER) human epidermal growth factor receptor-2 (HER2) and several signaling molecules against multiple BC cell lines and sensitize cancer cell lines to this compound when used at an optimal inhibitory concentration. More specifically, GNT mediates the anticancer mechanism through apoptosis induction, arresting the cell cycle, inhibiting angiogenesis and metastasis, mammosphere formation, and targeting and suppressing tumor growth factors. Furthermore, it acts via upregulating tumor suppressor genes and downregulating oncogenes in vitro and animal model studies. In addition, this phytochemical synergistically reverses the resistance mechanism of standard chemotherapeutic drugs, increasing their efficacy against BC. Overall, in this review, we discuss several molecular interactions of GNT with numerous cellular targets in the BC model and show its anticancer activities alone and synergistically. We conclude that GNT can have favorable therapeutic advantages when standard drugs are not available in the pharma markets.

【 授权许可】

Unknown