New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents

International Journal of Molecular Sciences

Kuo-Ting Chen¹  Yann Seimbille² 

[1] Department of Chemistry, National Dong Hwa University, Hualien 974301, Taiwan;Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands;

关键词: carbonic anhydrase IX;    cancer;    imaging agents;    PET;    SPECT;    fluorescence imaging;   

DOI  :  10.3390/ijms23116125

来源: DOAJ

【 摘 要 】

Carbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the molecular imaging of solid malignancies. The nuclear- and optical-imaging of CAIX-expressing tumors have received great attention due to their potential for clinical applications. Nuclear imaging is a powerful tool for the non-invasive diagnosis of primary and metastatic CAIX-positive tumors and for the assessment of responses to antineoplastic treatment. Intraoperative optical fluorescence imaging provides improved visualization for surgeons to increase the discrimination of tumor lesions, allowing for safer surgical treatment. Over the past decades, many CAIX-targeted molecular imaging probes, based on monoclonal antibodies, antibody fragments, peptides, and small molecules, have been reported. In this review, we outline the recent development of CAIX-targeted probes for single-photon emission computerized tomography (SPECT), positron emission tomography (PET), and near-infrared fluorescence imaging (NIRF), and we discuss issues yet to be addressed.

【 授权许可】

Unknown