The Relationship Between Anti-Hypertensive Drugs and Cancer: Anxiety to be Resolved in Urgent

Frontiers in Pharmacology

Yi Yao¹  Rong Yang¹  Chuanying Huang¹  Xiaoyang Liao¹  Yonggang Zhang²  Lixia Liu³ 

[1] Department of International Medical Center/Ward of General Practice, West China Hospital, Sichuan University, Chengdu, China;Department of Periodical Press and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China;Health Management Center, West China Hospital, Sichuan University, Chengdu, China;

关键词: anti-hypertensive drugs;    cancer;    mechanisms;    cancer risk;    adjuvant therapy;   

DOI  :  10.3389/fphar.2020.610157

来源: DOAJ

【 摘 要 】

Hypertension is the prevailing independent risk factor for cardiovascular disease worldwide. Anti-hypertensive drugs are the common and effective cure for lowering blood pressure in patients with hypertension. However, some large-scale clinical studies have pointed out that long-term ingestion of some oral anti-hypertensive drugs was associated with risks of incident cancer and the survival time. In contrast, other studies argue that anti-hypertensive drugs are not related to the occurrence of cancer, even as a complementary therapy of tumor treatment. To resolve the dispute, numerous recent mechanistic studies using animal models have tried to find the causal link between cancer and different anti-hypertensive drugs. However, the results were often contradictory. Such uncertainties have taken a toll on hypertensive patients. In this review, we will summarize advances of longitudinal studies in the association between anti-hypertensive drugs and related tumor risks that have helped to move the field forward from associative to causative conclusions, in hope of providing a reference for more rigorous and evidence-based clinical research on the topic to guide the clinical decision making.

【 授权许可】

Unknown