One-Step Synthesis of Silver Nanoparticles on Polydopamine-Coated Sericin/Polyvinyl Alcohol Composite Films for Potential Antimicrobial Applications

Molecules

Yejing Wang¹  Rui Cai¹  Hua Zuo²  Huawei He³  Gang Tao³  Wenchao Jiang³  Kai Song³ 

[1] College of Biotechnology, Southwest University, Beibei, Chongqing 400715, China;College of Pharmaceutical Sciences, Southwest University, Beibei, Chongqing 400715, China;State Key Laboratory of Silkworm Genome Biology, Southwest University, Beibei, Chongqing 400715, China;

关键词: sericin;    polyvinyl alcohol;    polydopamine;    silver nanoparticles;    one-step synthesis;    antibacterial activity;   

DOI  :  10.3390/molecules22050721

来源: DOAJ

【 摘 要 】

Silk sericin has great potential as a biomaterial for biomedical applications due to its good hydrophilicity, reactivity, and biodegradability. To develop multifunctional sericin materials for potential antibacterial application, a one-step synthesis method for preparing silver nanoparticles (AgNPs) modified on polydopamine-coated sericin/polyvinyl alcohol (PVA) composite films was developed. Polydopamine (PDA) acted as both metal ion chelating and reducing agent to synthesize AgNPs in situ on the sericin/PVA composite film. Scanning electron microscopy and energy dispersive spectroscopy analysis revealed that polydopamine could effectively facilitate the high-density growth of AgNPs as a 3-D matrix. X-ray diffractometry studies suggested the synthesized AgNPs formed good face-centered cubic crystalline structures. Contact angle measurement and mechanical test indicated AgNPs modified PDA-sericin/PVA composite film had good hydrophilicity and mechanical property. The bacterial growth curve and inhibition zone assays showed the AgNPs modified PDA-sericin/PVA composite film had long-term antibacterial activities. This work develops a new method for the preparation of AgNPs modified PDA-sericin/PVA film with good hydrophilicity, mechanical performance and antibacterial activities for the potential antimicrobial application in biomedicine.

【 授权许可】

Unknown