Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan

Frontiers in Oncology

Chih-Ching Yeh³  Fung-Chang Sung⁶  Thi Nga Le⁸  Chih-Hsin Muo⁹  Arlene Te^1,10  Chyi-Huey Bai^1,11  Fu-Hsiung Su^1,11  Shih-Ni Chang^1,12 

[1] 0Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan;1Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan;2Master Program in Applied Molecular Epidemiology, College of Public Health, Taipei Medical University, Taipei, Taiwan;Big Data Center, China Medical University Hospital, Taichung, Taiwan;Department of Family Medicine, Cardinal Tien Hospital, Fu Jen Catholic University, New Taipei City, Taiwan;Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan;Department of Health Services Administration, College of Public Health, China Medical University, Taichung, Taiwan;International Master/PhD Program, College of Medicine, Taipei Medical University, Taipei City, Taiwan;Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan;School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan;The Ph.D. Program for Cancer Biology and Drug Discovery, School of Medicine, China Medical University, Taichung, Taiwan;

关键词: hepatitis C virus;    colorectal cancer;    population-based;    case-control study;    insurance data;   

DOI  :  10.3389/fonc.2020.561420

来源: DOAJ

【 摘 要 】

AimStudies evaluating colorectal cancer (CRC) risk associated with chronic hepatitis C virus (HCV) infection are limited.MethodsIn this case-control study, we identify 67,670 CRC cases newly diagnosed from 2005 to 2011 and randomly selected 67,670 controls without HCV and CRC from the same database, frequency matched by age and sex of cases.ResultsResults of logistic regression analysis revealed that the adjusted odds ratio (aOR) of CRC was 1.16 (95% confidence interval [CI] = 1.08–1.24, p < 0.001) in association with chronic HCV. The CRC risk was slightly greater for women than for men. The risk decreased with age, with the aOR decreased from 2.26 (95% CI = 1.32–3.87, p = 0.003) in patients under 45 years old to 1.31 (95% CI = 1.10–1.55, p = 0.03) in patients aged 50–59, and 1.10 (95% CI = 1.00–1.22, p = 0.061) in patients aged over 70.ConclusionsOur findings suggested that patients with chronic HCV infection are at an elevated risk of developing CRC. Our data also imply that the CRC prevention programs are needed to target younger HCV patients.

【 授权许可】

Unknown