Antiviral and Inflammatory Cellular Signaling Associated with Enterovirus 71 Infection

Viruses

Guangcai Duan¹  Yuefei Jin¹  Rongguang Zhang¹  Weidong Wu² 

[1] Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China;Department of Occupational and Environmental Health, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China;

关键词: EV71;    antiviral innate immunity;    cellular signaling;    immune evasion;    inflammatory response;   

DOI  :  10.3390/v10040155

来源: DOAJ

【 摘 要 】

Enterovirus 71 (EV71) infection has become a major threat to global public health, especially in infants and young children. Epidemiological studies have indicated that EV71 infection is responsible for severe and even fatal cases of hand, foot, and mouth disease (HFMD). Accumulated evidence indicates that EV71 infection triggers a plethora of interactive signaling pathways, resulting in host immune evasion and inflammatory response. This review mainly covers the effects of EV71 infection on major antiviral and inflammatory cellular signal pathways. EV71 can activate cellular signaling networks including multiple cell surface and intracellular receptors, intracellular kinases, calcium flux, and transcription factors that regulate antiviral innate immunity and inflammatory response. Cellular signaling plays a critical role in the regulation of host innate immune and inflammatory pathogenesis. Elucidation of antiviral and inflammatory cellular signaling pathways initiated by EV71 will not only help uncover the potential mechanisms of EV71 infection-induced pathogenesis, but will also provide clues for the design of therapeutic strategies against EV71 infection.

【 授权许可】

Unknown