Evasion of Host Antiviral Innate Immunity by Paramyxovirus Accessory Proteins

Frontiers in Microbiology

Microbiology

Ting Wang¹  Hui Chen¹  Xiangwei Wang¹  Sa Xiao¹  Chongyang Wang¹  Haijin Liu¹  Juan Wang¹  Liuyuan Duan¹  Shuxia Zhang¹  Ruochen Hu¹  Yanqing Jia¹  Xinglong Wang¹  Zhili Chu¹  Ruyi Dang²  Zengqi Yang² 

[1] College of Veterinary Medicine, Northwest A&F University, Xianyang, China;null;

关键词: paramyxoviruses;    immune evasion;    accessory proteins;    IFN;    antiviral innate immunity;   

DOI  :  10.3389/fmicb.2021.790191

 received in 2021-10-06, accepted in 2021-12-22,  发布年份 2022

来源: Frontiers

【 摘 要 】

For efficient replication, viruses have developed multiple strategies to evade host antiviral innate immunity. Paramyxoviruses are a large family of enveloped RNA viruses that comprises diverse human and animal pathogens which jeopardize global public health and the economy. The accessory proteins expressed from the P gene by RNA editing or overlapping open reading frames (ORFs) are major viral immune evasion factors antagonizing type I interferon (IFN-I) production and other antiviral innate immune responses. However, the antagonistic mechanisms against antiviral innate immunity by accessory proteins differ among viruses. Here, we summarize the current understandings of immune evasion mechanisms by paramyxovirus accessory proteins, specifically how accessory proteins directly or indirectly target the adaptors in the antiviral innate immune signaling pathway to facilitate virus replication. Additionally, some cellular responses, which are also involved in viral replication, will be briefly summarized.

【 授权许可】

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Copyright © 2022 Wang, Wang, Duan, Chen, Hu, Wang, Jia, Chu, Liu, Wang, Zhang, Xiao, Wang, Dang and Yang.