Hen collagen hydrolysate alleviates UVA-induced damage in human dermal fibroblasts

Journal of Functional Foods

Jianping Wu¹  Xiaofeng Wang²  Hui Hong² 

[1] Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China;Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada;

关键词: Collagen hydrolysate;    Discoidin domain receptor 2;    Fibroblasts;    Skin aging;    UVA;   

DOI  :  

来源: DOAJ

【 摘 要 】

Collagen hydrolysate (CH) and peptides may have anti-aging properties on skin. In this study, CH prepared from the skin of porcine, bovine, tilapia, and hen were supplemented to human dermal fibroblasts (HDF) with UVA-exposure. Bovine CH inhibited matrix metalloproteinases (MMP)-1 synthesis. Tilapia CH promoted cell viability and pro-collagen I production, while inhibited the generation of reactive oxygen species (ROS) and MMP-1 in UVA-exposed HDF cells. Hen CH improved viability and pro-collagen I production, alleviated the expression of apoptotic genes, reduced ROS, MMP-1, and MMP-9 production, induced discoidin domain receptor 2 (DDR2) phosphorylation, and inhibited UVA-induced Akt and ERK1/2 phosphorylation in HDF cells, an effect largely comparable with a collagen-derived tripeptide Gly-Pro-Hyp. These results indicate that hen skin CH is superior to porcine, bovine, and tilapia skin CH on the protection of UVA-induced damage in fibroblast, with DDR2 being at least partially involved.

【 授权许可】

Unknown