Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae)

Acta Amazonica

Mariângela Soares de Azevedo¹  Elise Marques Freire Cunha¹  Larissa Dias Menezes²  Mônica Valero da Silva²  Gúbio Oliveira Gomes²  José Antônio Paixão da Silva Neto²  Vania Moraes Ferreira² 

[1] Universidade Federal de Rondônia;Universidade de Brasília;

关键词: Oil and Water Cream;    medicinal plant;    paw edema test;    formalin test;   

DOI  :  10.1590/S0044-59672014000200012

来源: DOAJ

【 摘 要 】

Alho do mato (Cipura paludosa, Iridaceae) is a medicinal plant found in the Amazon rain forest, North of Brazil. It has been used to treat algic, inflammatory and infectious processes. The aim of this study was to evaluate the anti-inflammatory and antinociceptive action of the crude Cipura paludosa ethanolic extract at concentrations ranging between 2.0 and 4.0% in Oil and Water cream formulations for topical use. The physical-chemical stability of the formulations was monitored over a six-month period with the use of accelerated stability tests. In order to evaluate the anti-inflammatory and antinociceptive activities, we used a paw edema test induced by carrageenan and a formalin test, respectively. The paw edema test showed that there was a statistical difference in the control group in relation to the treatments. The formalin test did not confirm antinociceptive action of the treatments with the extract in the early phase of the test. However, statistical difference was confirmed for the treatments in relation to the control in the late phase. The antinociceptive and anti-inflammatory activities of Cipura paludosa preparations, as demonstrated in the results, at least partially support the ethno-medical uses of this plant.

【 授权许可】

Unknown