Acta Amazonica | |
Evaluation of antinociceptive and anti-inflammatory activities of the topical preparation of Cipura paludosa (Iridaceae) | |
José Antônio Paixão Da Silva Neto2  Larissa Dias Menezes2  Gúbio Oliveira Gomes2  Elise Marques Freire Cunha1  Mariângela Soares De Azevedo1  Vania Moraes Ferreira2  Mônica Valero Da Silva2  | |
[1] ,Universidade de Brasília Departamento de Ciências Farmacêuticas Faculdade de Ciências da SaúdeBrasília DF ,Brazil | |
关键词: Oil and Water Cream; medicinal plant; paw edema test; formalin test; Creme óleo e água; planta medicinal; teste edema de pata; teste de formalina; | |
DOI : 10.1590/S0044-59672014000200012 | |
来源: SciELO | |
【 摘 要 】
Alho do mato (Cipura paludosa, Iridaceae) is a medicinal plant found in the Amazon rain forest, North of Brazil. It has been used to treat algic, inflammatory and infectious processes. The aim of this study was to evaluate the anti-inflammatory and antinociceptive action of the crude Cipura paludosa ethanolic extract at concentrations ranging between 2.0 and 4.0% in Oil and Water cream formulations for topical use. The physical-chemical stability of the formulations was monitored over a six-month period with the use of accelerated stability tests. In order to evaluate the anti-inflammatory and antinociceptive activities, we used a paw edema test induced by carrageenan and a formalin test, respectively. The paw edema test showed that there was a statistical difference in the control group in relation to the treatments. The formalin test did not confirm antinociceptive action of the treatments with the extract in the early phase of the test. However, statistical difference was confirmed for the treatments in relation to the control in the late phase. The antinociceptive and anti-inflammatory activities of Cipura paludosa preparations, as demonstrated in the results, at least partially support the ethno-medical uses of this plant.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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