Naloxegol hydrogen oxalate displaying a hydrogen-bonded layer structure

Acta Crystallographica Section E: Crystallographic Communications

Marijan Stefinovic¹  Thomas Gelbrich²  Christoph Langes²  Ulrich J. Griesser² 

[1] Sandoz GmbH, Biochemiestrasse 10, 6250 Kundl, Austria;University of Innsbruck, Institute of Pharmacy, Innrain 52, 6020 Innsbruck, Austria;

关键词: crystal structure;    hydrogen bonding;    topology;    oxalate;    pharmaceuticals;   

DOI  :  10.1107/S2056989018003675

来源: DOAJ

【 摘 要 】

In the salt (5α,6α)-6-[(2,5,8,11,14,17,20-heptaoxadocosan-22-yl)oxy]-3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5-epoxymorphinan-17-ium hydrogen oxalate, C34H54NO11+·C2HO4− the polyether unit of the naloxegol cation adopts the shape of a squashed open letter `O'. In the crystal, the hydrogen oxalate anions are linked into a chain by O—H...O hydrogen bonds. Each naloxegol unit is hydrogen bonded to three hydrogen oxalate ions via two O—H...O and one N—H...O interactions. The resulting hydrogen-bonded two-dimensional layer structure is 3,5-connected and has the 3,5 L50 topology.

【 授权许可】

Unknown