Emerging Roles of TRIM8 in Health and Disease

Cells

Luisa Guerrini¹  Elisabetta Sbisಠ Apollonia Tullo³  Graziano Pesole³  Flaviana Marzano³ 

[1] Department of Biosciences, Università degli Studi di Milano, 20133 Milan, Italy;Institute of Biomedical Technologies, National Research Council, CNR, 70126 Bari, Italy;Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, CNR, 70126 Bari, Italy;

关键词: TRIM8;    p53;    NF-κB;    JAK-STAT;   

DOI  :  10.3390/cells10030561

来源: DOAJ

【 摘 要 】

The superfamily of TRIM (TRIpartite Motif-containing) proteins is one of the largest groups of E3 ubiquitin ligases. Among them, interest in TRIM8 has greatly increased in recent years. In this review, we analyze the regulation of TRIM8 gene expression and how it is involved in many cell reactions in response to different stimuli such as genotoxic stress and attacks by viruses or bacteria, playing a central role in the immune response and orchestrating various fundamental biological processes such as cell survival, carcinogenesis, autophagy, apoptosis, differentiation and inflammation. Moreover, we show how TRIM8 functions are not limited to ubiquitination, and contrasting data highlight its role either as an oncogene or as a tumor suppressor gene, acting as a “double-edged weapon”. This is linked to its involvement in the selective regulation of three pivotal cellular signaling pathways: the p53 tumor suppressor, NF-κB and JAK-STAT pathways. Lastly, we describe how TRIM8 dysfunctions are linked to inflammatory processes, autoimmune disorders, rare developmental and cardiovascular diseases, ischemia, intellectual disability and cancer.

【 授权许可】

Unknown