Mixed Etiology COVID-19 Associated Pulmonary Aspergillosis (CAPA)—A Case Report and Brief Review of the Literature

Journal of Fungi

Razvan Marian Mihaila¹  Sandor Botond Buksa¹  Carmen Costache²  Ioana Alina Colosi²  Roxana Mihaela Chiorescu²  Dan Alexandru Toc²  Alexandru Botan² 

[1] Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania;Department of Microbiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania;

关键词: COVID19;    CAPA;    IPA;    Aspergillus section Flavi;    Aspergillus section Fumigati;    Romania;   

DOI  :  10.3390/jof7100877

来源: DOAJ

【 摘 要 】

The SARS-CoV-2 pandemic has proved to be a significant risk addition for invasive infections with Aspergillus. Even though there are plenty of data about the COVID-19-associated pulmonary aspergillosis (CAPA), especially involving Aspergillus fumigatus, recent studies are presenting cases of CAPA involving more than one species of Aspergillus. We report the first case of a SARS-CoV-2 patient associating co-infection with, most likely, Aspergillus section Fumigati and Aspergillus section Flavi from Romania, and we review the existing medical literature in order to shed light upon mixed etiology cases of CAPA. Since mortality remains high in these cases, there is an acute need for more information about the interaction between SARS-CoV-2 and Aspergillus spp., and the therapies for CAPA. The emerging number of cases and the high mortality rate must be considered an incentive for future research.

【 授权许可】

Unknown