期刊论文详细信息
Journal of Fungi
Association of COVID-19-Associated Pulmonary Aspergillosis with Cytomegalovirus Replication: A Case–Control Study
Jorge Calderón-Parra1  Elena Muñez-Rubio1  Ana Fernández-Cruz1  Patricia Mills-Sanchez1  Victor Moreno-Torres1  Antonio Ramos-Martinez1  Sandra Tejado-Bravo2  Bárbara Balandin-Moreno2  Isabel Romero-Sánchez3  Sarela García-Masedo4  Francisca Portero-Azorín4  Marina Calvo-Salvador4 
[1] Infectious Diseases Unit, Service of Internal Medicine, Hospital Universitario Puerta de Hierro, 28222 Majadahonda, Spain;Intensive Care Unit, Hospital Universitario Puerta de Hierro, 28222 Majadahonda, Spain;Microbiology Service, Hospital Universitario Puerta de Hierro, 28222 Majadahonda, Spain;Pharmacy Service, Hospital Universitario Puerta de Hierro, 28222 Majadahonda, Spain;
关键词: COVID-associated pulmonary aspergillosis;    CAPA;    prevalence;    risk factors;    cytomegalovirus infection;   
DOI  :  10.3390/jof8020161
来源: DOAJ
【 摘 要 】

Introduction: Cytomegalovirus (CMV) infection is a well-known factor associated with invasive aspergillosis in immunocompromised hosts. However, its association with COVID-19-associated pulmonary aspergillosis (CAPA) has not been described. We aimed to examine the possible link between CMV replication and CAPA occurrence. Methods: A single-center, retrospective case–control study was conducted. A case was defined as a patient diagnosed with CAPA according to 2020 ECMM/ISHAM consensus criteria. Two controls were selected for each case among critically ill COVID-19 patients. Results: In total, 24 CAPA cases were included, comprising 14 possible CAPA and 10 probable CAPA. Additionally, 48 matched controls were selected. CMV replication was detected more frequently in CAPA than in controls (75.0% vs. 35.4%, p = 0.002). Probable CMV end-organ disease was more prevalent in CAPA (20.8% vs. 4.2%, p = 0.037). After adjusting for possible confounding factors, CMV replication persisted strongly associated with CAPA (OR 8.28 95% CI 1.90–36.13, p = 0.005). Among 11 CAPA cases with CMV PCR available prior to CAPA, in 9 (81.8%) cases, CMV replication was observed prior to CAPA diagnosis. Conclusions: Among critically ill COVID-19 patients, CMV replication was associated with CAPA and could potentially be considered a harbinger of CAPA. Further studies are needed to confirm this association.

【 授权许可】

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