Hylocereus polyrhizus Peel Extract Retards Alcoholic Liver Disease Progression by Modulating Oxidative Stress and Inflammatory Responses in C57BL/6 Mice

Nutrients

Jung Ko¹  Hsin-Yi Yang²  Wan-Ju Yeh³  Chia-Chun Tsai⁴ 

[1] Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-3584, Japan;Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan;Graduate Program of Nutrition Science, National Taiwan Normal University, Taipei 106, Taiwan;School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan;

关键词: alcoholic liver disease;    red pitaya;    fatty liver;    oxidative stress;    inflammation;   

DOI  :  10.3390/nu12123884

来源: DOAJ

【 摘 要 】

Alcoholic liver disease (ALD) has become a health problem as alcohol consumption has increased annually. Hepatic lipid accumulation, oxidative stress, and inflammation are important factors in the progression of ALD. Red pitaya (Hylocereus polyrhizus (Weber) Britt. & Rose) peel is rich in polyphenols and betanins, which possess antioxidative and anti-inflammatory properties. Therefore, the aim of this study was to investigate the effects of red pitaya peel extract (PPE) on ALD and explore the associated mechanisms. C57BL/6 J mice were administered an ethanol liquid diet for 11 weeks with or without two different doses of PPE (500 and 1000 mg/kg BW). PPE treatment significantly ameliorated liver injury and hepatic fat accumulation, and it improved hepatic lipid metabolism via increases in AMPK and PPAR-α protein expression and a decrease in SREBP-1 expression. In addition, PPE inhibited CYP2E1 and Nrf2 protein expression, reduced endotoxin levels in the serum, and decreased TLR4 and MyD88 expression and inflammatory cytokine TNF-α and IL-1β levels in the liver. In conclusion, these findings suggest that PPE may prevent the progression of ALD by modulating lipid metabolism and reducing oxidative stress and inflammatory responses.

【 授权许可】

Unknown