STRENGTH OF ANTI-DIPHTHERIA AND ANTI-TETANUS IMMUNITY IN HIV-INFECTED ADULTS

Вісник проблем біології і медицини

Revenko H. O.¹ 

[1] Dnipropetrovsk State Medical Academy, MOH of Ukraine ;

关键词: hiv infection;    vaccination;    immunity;    seroprevalence;    diphtheria;    tetanus.;   

DOI  :  10.29254/2077-4214-2020-4-158-178-182

来源: DOAJ

【 摘 要 】

Effective antiretroviral therapy has transformed HIV into a manageable disease, therefore the issue of immunological prophylaxis of infectious diseases among these patients arises. Diphtheria and tetanus can only be prevented by vaccination. The purpose of the study was to assess the status of post-vaccination immunity against diphtheria and tetanus by investigating the seroprevalence of antibodies against these infections in HIV-infected adults. The total of 90 HIV-infected patients aged 22 to 60 years were examined (main group). The control group consisted of 49 immunocompetent volunteers of the corresponding age. Determination of the anti-diphtheria and anti-tetanus antibodies levels was carried out by means of immunoassay analysis using RIDASCREEN Diphtheria IgG and RIDASCREEN Tetanus IgG (R-Biopharm AG, Germany) diagnostic test systems. Statistical processing was performed using the STATISTICA v.6.1 licensed software. Significant differences were found between the titers of anti-toxic antibodies in HIV-infected and immunocompetent adults. The median of antidiphtherial antibodies in HIV-positive individuals was 0.17 (0.09-0.38) IU/ml, which is by 6.1 times lower than that in the control group – 1.03 (0.56-1.27) IU/ml (p<0.001 by the Mann-Whitney criterion). The median of anti-tetanus antibodies in the main group was 0.59 (0.28-1.09) IU/ml, which is by 2.3 times less than that in the control group – 1.33 (1.13-1.45) IU/ml (p<0.001). The population unprotected against diphtheria among the main group was 93.3% (n=84), against tetanus – 52.2% (n=47). There was no reliable association between the levels of antitoxic antibodies against diphtheria and tetanus and the number of CD4+ T-lymphocytes in HIV-infected individuals. HIV-positive adults constitute a risk group for potential diphtheria and tetanus as they have low specific immunity. It justifies their mandatory vaccination against these infectious diseases.

【 授权许可】

Unknown