Seropositivity for hepatitis B virus, vaccination coverage, and vaccine response in dentists from Campo Grande, Mato Grosso do Sul, Brazil

Memórias do Instituto Oswaldo Cruz

Sonia Mf Batista²  Márcia Sa Andreasi²  Ana Mt Borges¹  Andréa Sc Lindenberg¹  Anísio L Silva²  Thiago D Fernandes²  Edy F Pereira²  Eline Am Basmage¹  Divina Dp Cardoso¹ 

[1] ,Universidade Federal de Mato Grosso do Sul Centro de Ciências Biológicas e da Saúde Departamento de PatologiaCampo Grande MS ,Brasil

关键词: hepatitis B;    dentists;    vaccination;    seroprevalence;    Brazil;   

DOI  :  10.1590/S0074-02762006000300006

来源: SciELO

【 摘 要 】

This study investigated the seropositivity for hepatitis B virus (HBV), the vaccination index, and the vaccine response index in dentists from Campo Grande, MS. Blood samples from 474 dentists (63.7% women and 36.3% men), with a mean age of 38.5 ± 10.5 years were analyzed by enzyme-linked immunosorbent assay to detect the serological markers: HBsAg, anti-HBs, and anti-HBc. The HBsAg positive samples were tested for anti-HBc IgM, HBeAg, and anti-HBe. A total of 51 (10.8%) dentists showed seropositivity for HBV. Three (0.6%) were HBsAg/anti-HBc/anti-HBe positive, 43 (9.1%) were anti-HBc/anti-HBs positive, and 5 (1.1%) had only anti-HBc. Viral DNA was detected by polymerase chain reaction in 9 (17.6%) out of 51 HBV seropositive samples. A vaccination index of 96.6% (458/474) was observed, although 73.1% (335/458)completed the three-dose schedule. Excluding 46 HBV seropositive individuals from 458 that reported vaccination, 412 were analyzed for vaccine response index. It was observed that 74.5% (307/412) were anti-HBs positive; this percentage increased to 79.1% when three doses were administered. The results showed a high vaccination index and a good rate of vaccine response; however, the failure in completing the three-dose schedule and the occurrence of HBV infection reinforce the need for more effective prevention strategies.

【 授权许可】

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