Modeling Challenge Data to Quantify Endogenous Lactate Production

Frontiers in Endocrinology

Darko Stefanovski¹  Raymond C. Boston²  Pamela A. Wilkins³ 

[1] Department of Clinical Studies – New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States;Department of Clinical Studies- New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States;Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana-Champaign, IL, United States;

关键词: lactate;    mathematical model;    horse;    metabolism;    infusion;    units;   

DOI  :  10.3389/fendo.2021.656054

来源: DOAJ

【 摘 要 】

With the intention of isolating the susceptibility of modeling methodology to influence our investigation of the infusion data, we used three kinetic approaches to our models: a simple approach, a unit approach, and a novel approach. The simple approach used exclusively built-in modeling features of the software in terms of units of the infusion dilution (mmol/L), as well as in terms of the precision of switching the infusion on and off. The unit approach used the same switching mechanism as the simple approach, but the units were modeled in those of the infusion (e.g., mmol/kg). Thirdly with the novel approach, we used an automated approach to controlling the infusion, in the sense that as the modeling mechanism sensed the slowdown of the infusion, it was gradually turned off. The units of the analysis for the novel approach were exactly the same as those deployed in the unit approach. Our objective here was to see if common pharmacokinetic parameters were seriously impacted by the particular modeling method.

【 授权许可】

Unknown