Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes

Nutrients

Chiara Cosma¹  Romina Valentini²  Annunziata Lapolla²  Giovanni Sartore²  Nino Cristiano Chilelli²  Stefania Ferraresso²  Eugenio Ragazzi³ 

[1] Department of Laboratory Medicine, University of Padova, 35100 Padova, Italy;Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy;Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35100 Padova, Italy;

关键词: advanced glycation end-products;    curcumin;    inflammation;    exercise;    oxidative stress;   

DOI  :  10.3390/nu8110745

来源: DOAJ

【 摘 要 】

Background: Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin and Boswellia serrata (BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists. Methods. Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group). Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), high-sensitivity c-reactive protein (hs-CRP), total AGE, soluble receptor for AGE (sRAGE), malondialdehyde (MDA), plasma phospholipid fatty acid (PPFA) composition, and non-esterified fatty acids (NEFA) were tested at baseline and after 12 weeks. Results: sRAGE, NEFA, and MDA decreased significantly in both groups, while only the curcumin/BSE group showed a significant decline in total AGE. Only the changes in total AGE and MDA differed significantly between the curcumin/BSE and MD groups. Conclusions. Our data suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes.

【 授权许可】

Unknown