Protocol: A randomized controlled trial to assess effectiveness of a 12-month lifestyle intervention to reduce cardiovascular disease risk in families ten years after pre-eclampsia (FINNCARE)

Preventive Medicine Reports

Michelle Renlund¹  Anni Kivelä²  Hannele Laivuori³  Minna Aittasalo⁴  Taisto Sarkola⁵  Seppo Heinonen⁶  Tiina Jääskeläinen⁶ 

[1] Corresponding author at: Faculty of Medicine, Department of Medical and Clinical Genetics, Biomedicum P.O. Box 63, FI 00014, University of Helsinki, Finland.;Department of Food and Nutrition, University of Helsinki, Helsinki, Finland;Minerva Foundation Institute for Medical Research, Helsinki, Finland;Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland;Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;

关键词: Cardiovascular disease;    Family;    Lifestyle intervention;    Pre-eclampsia;    Prevention;   

DOI  :  

来源: DOAJ

【 摘 要 】

Pre-eclampsia (PE) is a multisystem progressive disorder affecting 3–5% of pregnancies. PE independently increases the risk for premature cardiovascular disease (CVD) in mothers and their children long-term. The effectiveness of a family-centered lifestyle intervention to lower CVD risk in PE families has not previously been evaluated. In the current FINNCARE study, we prospectively compare CVD risk and CVD progression in PE families (mother, father and child) in a cross-sectional study setting 8–12 years from delivery with non-PE control families of comparable age. Furthermore, we evaluate the effectiveness and feasibility of an interactive web-based behavioral 12-month lifestyle intervention to reduce blood pressure and the CVD risk profile overall in a randomized controlled trial. In total, 300 PE families will be randomized 1:1 to a PE-intervention or a PE-control group, and the 100 non-PE control families similarly followed-up at 12 months. Primary outcome is 24-hour mean systolic BP change from baseline in mother and child. Study aims to provide information on CVD progression and CVD risk management in the family following PE.

【 授权许可】

Unknown