A Framework for Understanding the Evasion of Host Immunity by Candida Biofilms

Frontiers in Immunology

Katrien Lagrou²  Lotte Mathé³  Patrick Van Dijck³  Adrian Liston⁴  Stephanie Humblet-Baron⁴  Josselyn E. Garcia-Perez⁴  Annabel Braem⁶ 

[1] Center for Microbiology VIB – KU Leuven, Heverlee, Belgium;Clinical Department of Laboratory Medicine and National Reference Center for Mycosis, University Hospitals Leuven, Leuven, Belgium;Department of Materials Engineering (MTM), KU Leuven, Heverlee, Belgium;Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium;Laboratory of Translational Immunology, VIB Center for Brain and Disease Research, Leuven, Belgium;Surface and Interface Engineered Materials, Department of Materials Engineering (MTM), KU Leuven, Heverlee, Belgium;

关键词: biofilms;    Candida;    cytokines;    trained immunity;    immune resistance;   

DOI  :  10.3389/fimmu.2018.00538

来源: DOAJ

【 摘 要 】

Candida biofilms are a major cause of nosocomial morbidity and mortality. The mechanism by which Candida biofilms evade the immune system remains unknown. In this perspective, we develop a theoretical framework of the three, not mutually exclusive, models, which could explain biofilm evasion of host immunity. First, biofilms may exhibit properties of immunological silence, preventing immune activation. Second, biofilms may produce immune-deviating factors, converting effective immunity into ineffective immunity. Third, biofilms may resist host immunity, which would otherwise be effective. Using a murine subcutaneous biofilm model, we found that mice infected with biofilms developed sterilizing immunity effective when challenged with yeast form Candida. Despite the induction of effective anti-Candida immunity, no spontaneous clearance of the biofilm was observed. These results support the immune resistance model of biofilm immune evasion and demonstrate an asymmetric relationship between the host and biofilms, with biofilms eliciting effective immune responses yet being resistant to immunological clearance.

【 授权许可】

Unknown