Factors influencing recovery in patients with hemoblastoses and candidemia

Терапевтический архив

关键词: candidemia treatment;    echinocandins;    amphotericin b;    hemoblastoses;   

DOI  :  

来源: DOAJ

【 摘 要 】

Aim. To study the factors influencing the results of treatment for candidemia (CE) in patients with blood system tumors. Subjects and methods. The investigation enrolled patients with hemoblastoses and CE. 30-day all-cause mortality was analyzed. Results. In an 8-year period (2006—2013), CE was diagnosed in 55 patients (median age, 50 years); there was a preponderance of patients with lymphomas (47%) and acute leukemias (27%). The causative agents of CE were C. albicans (38%), С. parapsilosis (17%), С. krusei (11%), C. guilliermondii (11%), C. lusitaniae (6%), C. tropicalis (6%), С. glabrata (3%), С. famata (3%), C. pelliculosa (3%), and C. kefyr (2%). 30-day all-cause mortality was 43.6%. Recovery was statistically significantly more frequently seen following removal of a central venous catheter (67% versus 13%; p=0.004; odds ratio (OR), 14); after use of an antifungal drug on day 1 of isolation of Candida spp. from blood cultures (62% versus 13%; p=0.01; OR, 12); and that of echocandin as a first-line agent (86% versus 42%; p=0.005; OR, 8.4). The poor predictors were septic shock (5% recovery rate versus 86% in the patients without this factor; p

【 授权许可】

Unknown