The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium

Bioengineering

Reem El-Gendy¹  Nancy M. S. Hussein¹  Josie L. Meade¹  Hemant Pandit²  Elena Jones² 

[1] Division of Oral Biology, School of Dentistry, University of Leeds, Leeds LS2 9JT, UK;Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK;

关键词: diabetes;    periodontal disease;    mesenchymal stem cells;    bone regeneration;   

DOI  :  10.3390/bioengineering8120202

来源: DOAJ

【 摘 要 】

Periodontitis and diabetes mellitus (DM) are two of the most common and challenging health problems worldwide and they affect each other mutually and adversely. Current periodontal therapies have unpredictable outcome in diabetic patients. Periodontal tissue engineering is a challenging but promising approach that aims at restoring periodontal tissues using one or all of the following: stem cells, signalling molecules and scaffolds. Mesenchymal stem cells (MSCs) and insulin-like growth factor (IGF) represent ideal examples of stem cells and signalling molecules. This review outlines the most recent updates in characterizing MSCs isolated from diabetics to fully understand why diabetics are more prone to periodontitis that theoretically reflect the impaired regenerative capabilities of their native stem cells. This characterisation is of utmost importance to enhance autologous stem cells based tissue regeneration in diabetic patients using both MSCs and members of IGF axis.

【 授权许可】

Unknown