New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy

International Journal of Molecular Sciences

Marta Gonzalez-Alvarez¹  Isabel Gonzalez-Alvarez¹  Marival Bermejo¹  MariaDolores Marcos²  Felix Sancenon²  Virginia Merino²  AdrianH. Teruel²  Ramon Martinez-Mañez² 

[1] Engineering Department, Pharmacy and Pharmaceutical Technology Section, Miguel Hernandez University, 03550 Alicante, Spain;Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46022 Valencia, Spain;

关键词: intestinal permeability;    colon;    drug delivery;    inflammatory bowel diseases;   

DOI  :  10.3390/ijms21186502

来源: DOAJ

【 摘 要 】

Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in small intestine. This review focused on the reported contributions in the last four years to improve the effectiveness of treatments of inflammatory bowel diseases. The work concludes that there has been an increase in the development of CDDS in which pH, specific enzymes, reactive oxygen species (ROS), or a combination of all of these triggers the release. These delivery systems demonstrated a therapeutic improvement with fewer adverse effects. Future perspectives to the treatment of this disease include the elucidation of molecular basis of IBD diseases in order to design more specific treatments, and the performance of more in vivo assays to validate the specificity and stability of the obtained systems.

【 授权许可】

Unknown