Role of non-coding RNAs and RNA modifiers in cancer therapy resistance

Molecular Cancer

Honghua Zhou¹  Chan Li¹  Yuwei Wu¹  Qian Xu²  Zhaoya Liu³  Kai Xie⁴  Shuang Liu⁵  Yating Liu⁶  Xinyi Zhang⁶  Yongguang Tao⁶  Desheng Xiao⁶ 

[1] Department of Cardiovascular Medicine, Xiangya Hospital, Central South University;Department of Cardiovascular Surgery, Xiangya Hospital, Central South University;Department of Geriatrics, Third Xiangya Hospital, Central South University;Department of Neurosurgery, Xiangya Hospital, Central South University;Department of Oncology, Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University;Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, School of Basic Medicine, Central South University;

关键词: ncRNAs;    RNA modifiers;    Chemoresistance;    Radioresistance;   

DOI  :  10.1186/s12943-020-01171-z

来源: DOAJ

【 摘 要 】

Abstract As the standard treatments for cancer, chemotherapy and radiotherapy have been widely applied to clinical practice worldwide. However, the resistance to cancer therapies is a major challenge in clinics and scientific research, resulting in tumor recurrence and metastasis. The mechanisms of therapy resistance are complicated and result from multiple factors. Among them, non-coding RNAs (ncRNAs), along with their modifiers, have been investigated to play key roles in regulating tumor development and mediating therapy resistance within various cancers, such as hepatocellular carcinoma, breast cancer, lung cancer, gastric cancer, etc. In this review, we attempt to elucidate the mechanisms underlying ncRNA/modifier-modulated resistance to chemotherapy and radiotherapy, providing some therapeutic potential points for future cancer treatment.

【 授权许可】

Unknown