Prostate cancer and therapeutic challenges

Journal of Biological Research - Thessaloniki

Saad Ali S. Aljohani¹  Othman Rashed Alzahrani²  Atif Abdulwahab A. Oyouni²  Osama Mohamed Alamer³  Samar Abdullah Zailaie⁴  Yousef MohammedRabaa Hawsawi⁴ 

[1] Department of Basic Medical Sciences, Faculty of Medicine, Al-Rayan Colleges;Department of Biology, Faculty of Sciences, University of Tabuk;Department of Medical Laboratory Technology, Faculty of Applied Medical Science, University of Tabuk;Saudi Human Genome Program-Jeddah Satellite Laboratory, Research Center, King Faisal Specialist Hospital and Research Center, MBC-J04;

关键词: Prostate cancer;    Androgens;    Androgen receptor;    Anti-androgen therapy;    Heat-shock protein;   

DOI  :  10.1186/s40709-020-00128-z

来源: DOAJ

【 摘 要 】

Abstract Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential treatment for patients with metastatic PCs; however, acquired resistance to hormone deprivation and the transition to PC androgen independence is a major health obstacle. In this review, we aim to detail the roles of androgens, androgen receptors and sex steroid hormones in inducing apoptosis in PC.

【 授权许可】

Unknown