Prostate cancer and therapeutic challenges

Journal of Biological Research

article

Hawsawi, Yousef MohammedRabaa¹  Zailaie, Samar Abdullah¹  Oyouni, Atif Abdulwahab A.³  Alzahrani, Othman Rashed³  Alamer, Osama Mohamed⁴  Aljohani, Saad Ali S.⁵ 

[1] Saudi Human Genome Program-Jeddah Satellite Laboratory, Research Center, King Faisal Specialist Hospital and Research Center;College of Medicine, Al-Faisal University;Department of Biology, Faculty of Sciences, University of Tabuk;Department of Medical Laboratory Technology, Faculty of Applied Medical Science, University of Tabuk;Department of Basic Medical Sciences, Faculty of Medicine, Al-Rayan Colleges

关键词: Prostate cancer;    Androgens;    Androgen receptor;    Anti-androgen therapy;    Heat-shock protein;   

DOI  :  10.1186/s40709-020-00128-z

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential treatment for patients with metastatic PCs; however, acquired resistance to hormone deprivation and the transition to PC androgen independence is a major health obstacle. In this review, we aim to detail the roles of androgens, androgen receptors and sex steroid hormones in inducing apoptosis in PC.

【 授权许可】

CC BY-NC