Dietary hydroxytyrosol and hydroxytyrosyl acetate supplementation prevent pristane-induced systemic lupus erythematous in mice

Journal of Functional Foods

José G. Fernández-Bolaños¹  Alejandro González-Benjumea¹  Marina Aparicio-Soto²  Ana Cárdeno²  Catalina Alarcón-de-la-Lastra²  Marina Sánchez-Hidalgo² 

[1] Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Profesor García González Street 1, 41012 Seville, Spain;Department of Pharmacology, Faculty of Pharmacy, University of Seville, Profesor García González Street 2, 41012 Seville, Spain;

关键词: Diet;    Immunomodulation;    Inflammation;    Lupus;    Phenols;    SLE;   

DOI  :  

来源: DOAJ

【 摘 要 】

Current experimental studies suggest a beneficial role of dietary phenolic compounds on prevention and management of immune-inflammatory disorders. Systemic lupus erythematosus (SLE), a multisystemic autoimmune chronic disease, remains without an effective and safe treatment. Thus, diet therapy could be a promising approach in SLE due to its potential prophylactic effects without the side effects of classical pharmacology. This study evaluates the effects of diets supplemented with phenolic compounds: hydroxytyrosol (HTy) and hydroxytyrosyl acetate (HTy-Ac) in pristane-induced SLE mice. Peritoneal macrophages and spleens were isolated and cultured to evaluate cytokines levels by Enzyme-Linked Immunosorbent Assay (ELISA). Renal changes of inflammatory markers and signaling pathways were determined by western blot. Dietary phenol supplementation significantly reduced pro-inflammatory cytokines and prevented renal damage with a considerably blockage of different inflammatory-related pathways suggesting that HTy and HTy-Ac supplementation might provide a basis for developing a new dietary strategy for prevention and management of SLE.

【 授权许可】

Unknown