Evaluation of anti-inflammatory, immunomodulatory, chemopreventive and wound healing potentials from Schinus terebinthifolius methanolic extract

Revista Brasileira de Farmacognosia

Lis E.s. Fedel-miyasato¹  Cândida A.l. Kassuya¹  Sarah A. Auharek¹  Anelise S.n. Formagio¹  Claudia A.l. Cardoso¹  Mariana O. Mauro¹  Andréa L. Cunha-laura¹  Antônio C.d. Monreal¹  Maria C. Vieira¹  Rodrigo J. Oliveira¹ 

关键词: Schinus terebinthifolius;    Inflammation;    Immunomodulation;    Micronucleus;    Comet assay;   

DOI  :  10.1016/j.bjp.2014.08.004

来源: SciELO

【 摘 要 】

Inflammatory and genetic alterations are related to the development of chronic diseases such as cancer. Schinus terebinthifolius Raddi, Anacardiaceae, is used in folk medicine to treat inflammation, wounds and tumors. This study evaluated the anti-inflammatory, immunomodulatory, chemopreventive, and wound healing potentials of the methanolic extract from the leaves of Schinus terebinthifolius. The chemical composition of the extract was characterized using preliminary analytical LC methods. The results showed that the anti-inflammatory activity of the methanolic extract was similar to that of dexamethasone for edema reduction. Also, it inhibited the leukocyte migration into the air pouch and decreased plasma extravasation. In addition, the methanolic extract showed a healing action similar to that observed with collagenase. The methanolic extract is not genotoxic nor mutagenic, and in contrast it has chemopreventive activity, which elicits a high percentage of damage reduction by comet and micronucleus assay, preferably by bioantimutagenic action. The methanolic extract induced apoptosis and enhanced splenic phagocytosis in animals treated with cyclophosphamide. The methanolic extract contents, resolved by LC, include phenolic acid and flavonoids. Our results suggest a therapeutic potential for the methanolic extract.

【 授权许可】

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