Evaluation of anti-inflammatory, immunomodulatory, chemopreventive and wound healing potentials from Schinus terebinthifolius methanolic extract

Revista Brasileira de Farmacognosia

Formagio, Anelise S.N.¹  Universidade Federal de Mato Grosso do Sul, Campo Grande, Brazil¹  Fedel-Miyasato, Lis E.S.¹  Oliveira, Rodrigo J.¹  Vieira, Maria C.¹  Kassuya, Cândida A.L.¹  Universidade Federal da Grande Dourados, Dourados, Brazil¹  Mauro, Mariana O.¹  Universidade Estadual de Mato Grosso do Sul, Dourados, Brazil¹  Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni, Brasil¹  Auharek, Sarah A.¹  Cardoso, Claudia A.L.¹  Monreal, Antônio C.D.¹  Cunha-Laura, Andréa L.¹ 

关键词: Schinus terebinthifolius;    Inflammation;    Immunomodulation;    Micronucleus;    Comet assay;   

DOI  :  10.1016/j.bjp.2014.08.004

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Inflammatory and genetic alterations are related to the development of chronic diseases such as cancer. Schinus terebinthifolius Raddi, Anacardiaceae, is used in folk medicine to treat inflammation, wounds and tumors. This study evaluated the anti-inflammatory, immunomodulatory, chemopreventive, and wound healing potentials of the methanolic extract from the leaves of Schinus terebinthifolius. The chemical composition of the extract was characterized using preliminary analytical LC methods. The results showed that the anti-inflammatory activity of the methanolic extract was similar to that of dexamethasone for edema reduction. Also, it inhibited the leukocyte migration into the air pouch and decreased plasma extravasation. In addition, the methanolic extract showed a healing action similar to that observed with collagenase. The methanolic extract is not genotoxic nor mutagenic, and in contrast it has chemopreventive activity, which elicits a high percentage of damage reduction by comet and micronucleus assay, preferably by bioantimutagenic action. The methanolic extract induced apoptosis and enhanced splenic phagocytosis in animals treated with cyclophosphamide. The methanolic extract contents, resolved by LC, include phenolic acid and flavonoids. Our results suggest a therapeutic potential for the methanolic extract.

【 授权许可】

Unknown