Botulinum Toxin as a Pain Killer: Players and Actionsin Antinociception

Toxins

Joohong Ahnn¹  Sun-Kyung Lee¹  Dong-Wan Kim¹ 

[1] Department of Life Science, School of Natural Science, Hanyang University, Seoul 133-791, Korea;

关键词: botulinum neurotoxin;    pain;    nociception;    neurotransmitter;    neuropeptide;    TRP;   

DOI  :  10.3390/toxins7072435

来源: DOAJ

【 摘 要 】

Botulinum neurotoxins (BoNTs) have been widely used to treat a variety of clinical ailments associated with pain. The inhibitory action of BoNTs on synaptic vesicle fusion blocks the releases of various pain-modulating neurotransmitters, including glutamate, substance P (SP), and calcitonin gene-related peptide (CGRP), as well as the addition of pain-sensing transmembrane receptors such as transient receptor potential (TRP) to neuronal plasma membrane. In addition, growing evidence suggests that the analgesic andanti-inflammatory effects of BoNTs are mediated through various molecular pathways. Recent studies have revealed that the detailed structural bases of BoNTs interact with their cellular receptors and SNAREs. In this review, we discuss the molecular and cellular mechanisms related to the efficacy of BoNTs in alleviating human pain and insights on engineering the toxins to extend therapeutic interventions related to nociception.

【 授权许可】

Unknown