Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats

Iranian Journal of Basic Medical Sciences

Mohammad Hasan Ansari¹  Shadi Salehi²  Gholam Hossein Farjah³  Bagher Pourheidar³ 

[1] Department ofBiochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;Neurophysiology Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;

关键词: Ischemia;    Reperfusion;    Spinal cord;    Saffron extract;   

DOI  :  10.22038/ijbms.2017.8364

来源: DOAJ

【 摘 要 】

Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P

【 授权许可】

Unknown