Oncostatin M Mediates Adipocyte Expression and Secretion of Stromal-Derived Factor 1

Biology

Hardy Hang¹  JenniferL. Bailey²  CarrieM. Elks² 

[1] Adipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA;Matrix Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA;

关键词: oncostatin M;    adipose tissue;    stromal-derived factor 1;    adipocyte;    inflammation;   

DOI  :  10.3390/biology8010019

来源: DOAJ

【 摘 要 】

Adipose tissue homeostasis depends on interactions between stromal cells, adipocytes, and the cytokines and chemokines they produce. The gp130 cytokine, oncostatin M (OSM), plays a role in adipose tissue homeostasis. Mice, lacking the OSM receptor (OSMR) in adipocytes (Osmr^FKO mice), exhibit derangements in adipose tissue, insulin sensitivity, and immune cell balance. Here, we describe a possible role for the chemokine stromal-derived factor 1 (SDF-1) in these alterations. We treated 3T3-L1 adipocytes with OSM and observed a suppression of SDF-1 gene expression and protein secretion, an effect which was partially blunted by OSMR knockdown. However, Osmr^FKO mice also exhibited decreased SDF-1 gene and protein expression in adipose tissue. These contrasting results suggest that the loss of adipocyte OSM–OSMR signaling in vivo may be indirectly affecting adipokine production and secretion by altering OSM target genes to ultimately decrease SDF-1 expression in the Osmr^FKO mouse. We conclude that adipocyte OSM–OSMR signaling plays a role in adipose tissue SDF-1 production and may mitigate its effects on adipose tissue homeostasis.

【 授权许可】

Unknown