Mesenchymal Stem Cells in the Treatment of New Coronavirus Pandemic: A Novel Promising Therapeutic Approach

Advanced Pharmaceutical Bulletin

Vahid Niazi¹  Amirjafar Adibi²  Mohsen Yazdani³  Zahra Molavi⁴  Zahra Niknam⁴  Hakimeh Zali⁴  Sara Razi⁴  Mohammad Mehdi Ranjbar⁵  Marzieh Sameni⁶  Seyed Amir Mirmotalebisohi⁶ 

[1] Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.;Departments of Orthopedics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.;Institute of Biochemistry and Biophysics, Tehran University, Tehran, Iran.;Proteomics Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.;Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran.;Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.;

关键词: covid-19;    sars-cov-2;    stem cell therapy;    mesenchymal stem cell;    cytokine storm;   

DOI  :  10.34172/apb.2022.023

来源: DOAJ

【 摘 要 】

After severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) outbreaks, coronavirus disease 2019 (COVID-19) is the third coronavirus epidemic that soon turned into a pandemic. This virus causes acute respiratory syndrome in infected people. The mortality rate of SARS-CoV-2 infection will probably rise unless efficient treatments or vaccines are developed. The global funding and medical communities have started performing more than five hundred clinical examinations on a broad spectrum of repurposed drugs to acquire effective treatments. Besides, other novel treatment approaches have also recently emerged, including cellular host-directed therapies. They counteract the unwanted responses of the host immune system that led to the severe pathogenesis of SARS-CoV-2. This brief review focuses on mesenchymal stem cell (MSC) principles in treating the COVID-19. The US clinical trials database and the world health organization database for clinical trials have reported 82 clinical trials (altogether) exploring the effects of MSCs in COVID-19 treatment. MSCs also had better be tried for treating other pathogens worldwide. MSC treatment may have the potential to end the high mortality rate of COVID-19. Besides, it also limits the long-term inability of survivors.

【 授权许可】

Unknown