Nonmechanical Roles of Dystrophin and Associated Proteins in Exercise, Neuromuscular Junctions, and Brains

Brain Sciences

Bailey Nichols¹  Toshifumi Yokota¹  Shin'ichi Takeda² 

[1] Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry;Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-higashi, Kodaira, Tokyo 187-8502, Japan;

关键词: dystrophin;    dystrophin-glycoprotein complex (DGC);    syntrophin;    exercise;    brain;    tadalafil (Cialis®);    sildenafil citrate (Viagra®);    muscular dystrophy;    neuronal nitric oxide synthase (nNOS);    two-hit hypothesis (two-hit theory);   

DOI  :  10.3390/brainsci5030275

来源: DOAJ

【 摘 要 】

Dystrophin-glycoprotein complex (DGC) is an important structural unit in skeletal muscle that connects the cytoskeleton (f-actin) of a muscle fiber to the extracellular matrix (ECM). Several muscular dystrophies, such as Duchenne muscular dystrophy, Becker muscular dystrophy, congenital muscular dystrophies (dystroglycanopathies), and limb-girdle muscular dystrophies (sarcoglycanopathies), are caused by mutations in the different DGC components. Although many early studies indicated DGC plays a crucial mechanical role in maintaining the structural integrity of skeletal muscle, recent studies identified novel roles of DGC. Beyond a mechanical role, these DGC members play important signaling roles and act as a scaffold for various signaling pathways. For example, neuronal nitric oxide synthase (nNOS), which is localized at the muscle membrane by DGC members (dystrophin and syntrophins), plays an important role in the regulation of the blood flow during exercise. DGC also plays important roles at the neuromuscular junction (NMJ) and in the brain. In this review, we will focus on recently identified roles of DGC particularly in exercise and the brain.

【 授权许可】

Unknown