In Vitro Metabolism of Phenylspirodrimanes Derived from the Indoor Fungus Stachybotrys

Toxins

Annika Jagels¹  Viktoria Lindemann¹  Florian Hübner¹  Matthias Behrens¹  Hans-Ulrich Humpf¹ 

[1] Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany;

关键词: Stachybotrys;    phenylspirodrimanes;    mycotoxins;    indoor;    metabolism;    high-resolution mass spectrometry;   

DOI  :  10.3390/toxins14060395

来源: DOAJ

【 摘 要 】

Fungi belonging to the genus Stachybotrys are frequently detected in water-damaged indoor environments, and a potential correlation between emerging health problems of inhabitants of affected housing and the fungi is controversially discussed. Secondary metabolites (i.e., mycotoxins) produced by Stachybotrys, such as the highly toxic macrocyclic trichothecenes (MCTs), are of potential concern to human health. The present study, however, focused on the potential effects of the more broadly and abundantly formed group of phenylspirodrimanes (PSDs). The phase I and II metabolism of four structurally different PSDs were investigated in vitro using hepatic models in combination with high-performance liquid chromatography high-resolution mass spectrometry (HPLC-HRMS) analysis. In addition to metabolite detection by HRMS, isolation and structure elucidation by nuclear magnetic resonance spectroscopy (NMR) was part of the conducted study as well.

【 授权许可】

Unknown