Ghrelin as a Biomarker of Stress: A Systematic Review and Meta-Analysis

Nutrients

Marion Trousselard¹  BrettAshley Gordon²  Farès Moustafa³  Charlotte Oris⁴  Jeannot Schmidt⁵  Jean-Baptiste Bouillon-Minois⁵  Frédéric Dutheil⁵  David Thivel⁶ 

[1] French Armed Forces Biomedical Research Institute, IRBA, Neurophysiology of Stress, Neuroscience and Operational Constraint Department, F-91223 Brétigny-sur-Orge, France;La Trobe University, Holsworth Research Initiative, Bendigo, 3083 Victoria, Australia;University Hospital of Clermont-Ferrand, CHU Clermont–Ferrand, Emergency Medicine, F-63000 Clermont–Ferrand, France;Université Clermont Auvergne, CNRS, INSERM, GReD, F-63000, Clermont-Ferrand, France;Université Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, F-63000 Clermont-Ferrand, France;Université Clermont Auvergne, Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological conditions [AME2P], F-63000 Clermont Ferrand, France;

关键词: appetite;    anxiety;    metabolism;    public health;    mental health;   

DOI  :  10.3390/nu13030784

来源: DOAJ

【 摘 要 】

Introduction: Ghrelin is an orexigenic hormone which favors food-seeking behavior and has been postulated to be a biomarker of stress. We conducted a systematic review and meta-analysis on the evolution of ghrelin levels following acute stress. Methods: The PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched for studies reporting ghrelin levels before and after acute stress in humans. Results: We included ten studies for a total of 348 patients. Acute stress (intervention) was always in a laboratory. Acute stress was psychological (Trier Social Stress Test), physical, or mixed (cold pressure test). The overall meta-analysis demonstrated an increase in ghrelin after the stress intervention (ES = 0.21, 95CI 0.09 to 0.34) compared with baseline levels. Stratification by time demonstrated an acute increase in ghrelin levels in the five minutes immediately following the initiation of stress (0.29, 0.10 to 0.48) but without any difference after. Obese individuals had a more significant (ES = 0.51, 95CI 0.18 to 0.84) and prolonged increase in ghrelin levels for up to 45 min compared with non-obese individuals who had a significant increase only five minutes after stress. Moreover, the ghrelin levels increased in response to stress with BMI (coefficient 0.028, 0.01 to 0.49; p = 0.013) and decreased with the time after the stress intervention (coefficient -0.007, −0.014 to −0.001; p = 0.025). Conclusion: Ghrelin is a biomarker of stress, with a short-term increase following acute stress. Obese individuals have both a higher and prolonged response, emphasizing the link between obesity and stress.

【 授权许可】

Unknown