Nanotechnology-Based Strategies to Develop New Anticancer Therapies

Biomolecules

Alberto Macone¹  Enzo Agostinelli¹  Massimiliano Magro²  Fabio Vianello²  Andrea Venerando²  Gianluca Canettieri³ 

[1] Department of Biochemical Sciences, A. Rossi Fanelli’, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy;Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell’Università 16, 35020 Legnaro (PD), Italy;Pasteur Laboratory, Department of Molecular Medicine, Sapienza University of Rome, I-00161 Rome, Italy;

关键词: nanoparticles;    polyamines;    hyperthermia;    amino oxidases;    biomolecules;    cancer;   

DOI  :  10.3390/biom10050735

来源: DOAJ

【 摘 要 】

The blooming of nanotechnology has made available a limitless landscape of solutions responding to crucial issues in many fields and, nowadays, a wide choice of nanotechnology-based strategies can be adopted to circumvent the limitations of conventional therapies for cancer. Herein, the current stage of nanotechnological applications for cancer management is summarized encompassing the core nanomaterials as well as the available chemical–physical approaches for their surface functionalization and drug ligands as possible therapeutic agents. The use of nanomaterials as vehicles to delivery various therapeutic substances is reported emphasizing advantages, such as the high drug loading, the enhancement of the pay-load half-life and bioavailability. Particular attention was dedicated to highlight the importance of nanomaterial intrinsic features. Indeed, the ability of combining the properties of the transported drug with the ones of the nano-sized carrier can lead to multifunctional theranostic tools. In this view, fluorescence of carbon quantum dots, optical properties of gold nanoparticle and superparamagnetism of iron oxide nanoparticles, are fundamental examples. Furthermore, smart anticancer devices can be developed by conjugating enzymes to nanoparticles, as in the case of bovine serum amine oxidase (BSAO) and gold nanoparticles. The present review is aimed at providing an overall vision on nanotechnological strategies to face the threat of human cancer, comprising opportunities and challenges.

【 授权许可】

Unknown